decreased insulin secretion_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Ins2-cre)25Mgn/0

http://metadb.riken.jp/0003059I129S6SvEvTacC57BL6DBAStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgIns2cre25Mgn0Stat5atm2MamTgIns2cre25MgnStat5btm1Mam

decreased insulin secretion_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Ins2-cre)25Mgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• signal transducer and activator of transcription 5B
  http://metadb.riken.jp/db/mgi_rdf/MGI:103035
• signal transducer and activator of transcription 5A
  http://metadb.riken.jp/db/mgi_rdf/MGI:103036
• transgene insertion 25, Mark A Magnuson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176225

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Ins2-cre)25Mgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Stat5a<tm2Mam>|Tg(Ins2-cre)25Mgn|Stat5b<tm1Mam>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6 * DBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased insulin secretion
  http://purl.obolibrary.org/obo/MP_0003059

文献

http://purl.org/net/cito/citesAsAuthority

• Ji-Yeon. Lee, et.al., The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging., Biochimica et biophysica acta, 2007, 1773
  http://rdf.ncbi.nlm.nih.gov/pubmed/17599554