thrombocytopenia_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0003179IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26Sortm1CAGNPM1GenoTgMx1cre1Cgn0TgMx1cre1CgnGtROSA26Sortm1CAGNPM1Geno

thrombocytopenia_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Mx1-cre)1Cgn|Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased platelet cell number
  http://purl.obolibrary.org/obo/MP_0003179

文献

http://purl.org/net/cito/citesAsAuthority

• Paolo. Sportoletti, et.al., The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model., Blood, 2013, 121
  http://rdf.ncbi.nlm.nih.gov/pubmed/23435463