decreased neuron apoptosis_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<+>

http://metadb.riken.jp/0003204I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53Trp53tm1BrdTrp53Lig4tm1Fwa

decreased neuron apoptosis_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• ligase IV, DNA, ATP-dependent
  http://metadb.riken.jp/db/mgi_rdf/MGI:1335098
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brd>|Trp53<+>|Lig4<tm1Fwa>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129S7/SvEvBrd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased neuron apoptosis
  http://purl.obolibrary.org/obo/MP_0003204

文献

http://purl.org/net/cito/citesAsAuthority

• K M. Frank, et.al., DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway., Molecular cell, 2000, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/10911993