K M. Frank, et.al., DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway., Molecular cell, 2000, 5

http://rdf.ncbi.nlm.nih.gov/pubmed/10911993

K M. Frank, et.al., DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway., Molecular cell, 2000, 5

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased thymocyte number_Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0000715I129S6SvEvTacC57BL6Lig4tm1FwaLig4tm1FwaLig4tm1Fwa
• prenatal lethality, incomplete penetrance_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0011101I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53tm1BrdLig4tm1FwaTrp53tm1Brd
• arrested B cell differentiation_Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0001802I129S6SvEvTacC57BL6Lig4tm1FwaLig4tm1FwaLig4tm1Fwa
• increased fibroblast proliferation_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0011703I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53tm1BrdLig4tm1FwaTrp53tm1Brd
• premature death_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002083I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53Trp53tm1BrdTrp53Lig4tm1Fwa
• increased neuron apoptosis_Cdkn2a<tm1Rdp>/Cdkn2a<+>,Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0003203I129Sv129S6SvEvTacC57BL6JSJLCdkn2atm1RdpCdkn2aLig4tm1FwaLig4tm1FwaLig4tm1FwaCdkn2atm1RdpCdkn2a
• decreased body weight_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0001262I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53Trp53tm1BrdTrp53Lig4tm1Fwa
• increased lymphoma incidence_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0012431I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53tm1BrdLig4tm1FwaTrp53tm1Brd
• prenatal lethality, incomplete penetrance_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0011101I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53Trp53tm1BrdTrp53Lig4tm1Fwa
• increased cellular sensitivity to ionizing radiation_Cdkn2a<tm1Rdp>/Cdkn2a<+>,Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0004227I129Sv129S6SvEvTacC57BL6JSJLCdkn2atm1RdpCdkn2aLig4tm1FwaLig4tm1FwaLig4tm1FwaCdkn2atm1RdpCdkn2a
• decreased neuron apoptosis_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0003204I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53Trp53tm1BrdTrp53Lig4tm1Fwa
• decreased cell proliferation_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0000352I129Sv129S6SvEvTacC57BL6JSJLCdkn2atm1RdpCdkn2atm1RdpLig4tm1FwaLig4tm1FwaLig4tm1FwaCdkn2atm1Rdp
• abnormal T cell differentiation_Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0002145I129S6SvEvTacC57BL6Lig4tm1FwaLig4tm1FwaLig4tm1Fwa
• decreased thymocyte number_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0000715I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53tm1BrdLig4tm1FwaTrp53tm1Brd
• premature death_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0002083I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53tm1BrdLig4tm1FwaTrp53tm1Brd
• decreased cell proliferation_Cdkn2a<tm1Rdp>/Cdkn2a<+>,Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0000352I129Sv129S6SvEvTacC57BL6JSJLCdkn2atm1RdpCdkn2aLig4tm1FwaLig4tm1FwaLig4tm1FwaCdkn2atm1RdpCdkn2a
• decreased neuron apoptosis_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0003204I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53tm1BrdLig4tm1FwaTrp53tm1Brd
• prenatal lethality, complete penetrance_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0011091I129Sv129S6SvEvTacC57BL6JSJLCdkn2atm1RdpCdkn2atm1RdpLig4tm1FwaLig4tm1FwaLig4tm1FwaCdkn2atm1Rdp
• increased B cell number_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0005014I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53tm1BrdLig4tm1FwaTrp53tm1Brd
• prenatal lethality, complete penetrance_Cdkn2a<tm1Rdp>/Cdkn2a<+>,Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0011091I129Sv129S6SvEvTacC57BL6JSJLCdkn2atm1RdpCdkn2aLig4tm1FwaLig4tm1FwaLig4tm1FwaCdkn2atm1RdpCdkn2a
• increased cellular sensitivity to ionizing radiation_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0004227I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53tm1BrdLig4tm1FwaTrp53tm1Brd
• decreased body weight_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0001262I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53tm1BrdLig4tm1FwaTrp53tm1Brd