neuron degeneration_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0

http://metadb.riken.jp/0003224I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz

neuron degeneration_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion E2, Huaibin Cai
  http://metadb.riken.jp/db/mgi_rdf/MGI:4420800
• solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:94862

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Slc6a3<+>|Tg(tetO-SNCA*A53T)E2Cai|Slc6a3<tm4.1(tTA)Xz>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• neuron degeneration
  http://purl.obolibrary.org/obo/MP_0003224

文献

http://purl.org/net/cito/citesAsAuthority

• Linan. Chen, et.al., A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, 35
  http://rdf.ncbi.nlm.nih.gov/pubmed/25609609