Linan. Chen, et.al., A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, 35

http://rdf.ncbi.nlm.nih.gov/pubmed/25609609

Linan. Chen, et.al., A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, 35

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Slc6a3<tm4.1(tTA)Xz>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5619093

class

http://purl.org/net/cito/citesAsAuthority

• Slc6a3<tm4.1(tTA)Xz>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5619093

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• neuron degeneration_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0003224I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz
• loss of dopaminergic neurons_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0003244I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz
• abnormal axon morphology_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0005404I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz
• decreased dopamine level_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0005643I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz
• abnormal mitochondrion morphology_Pink1<tm1Zhzh>/Pink1<tm1Zhzh>,Slc6a3<tm4.1(tTA)Xz>/?,Tg(tetO-SNCA*A53T)E2Cai/?
  http://metadb.riken.jp/0006035I129P2OlaHsd129S4SvJaeSor129S6SvEvTacC57BL6Pink1tm1ZhzhPink1tm1ZhzhSlc6a3tm41tTAXzTgtetOSNCAA53TE2CaiPink1tm1ZhzhSlc6a3tm41tTAXzTgtetOSNCAA53TE2Cai
• abnormal mitochondrion morphology_Park2<tm1Shn>/Park2<tm1Shn>,Slc6a3<tm4.1(tTA)Xz>/?,Tg(tetO-SNCA*A53T)E2Cai/?
  http://metadb.riken.jp/0006035I129S4SvJaeSor129S6SvEvTacC57BL6Park2tm1ShnPark2tm1ShnSlc6a3tm41tTAXzTgtetOSNCAA53TE2CaiPark2tm1ShnSlc6a3tm41tTAXzTgtetOSNCAA53TE2Cai
他8件を見る
• abnormal mitochondrial physiology_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0006036I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz
• abnormal dendrite morphology_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0008143I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz
• slow postnatal weight gain_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0008489I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz
• decreased mitochondria size_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0011631I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz
• abnormal mitochondrial shape_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0011633I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz
• neuronal cytoplasmic inclusions_Pink1<tm1Zhzh>/Pink1<tm1Zhzh>,Slc6a3<tm4.1(tTA)Xz>/?,Tg(tetO-SNCA*A53T)E2Cai/?
  http://metadb.riken.jp/0011975I129P2OlaHsd129S4SvJaeSor129S6SvEvTacC57BL6Pink1tm1ZhzhPink1tm1ZhzhSlc6a3tm41tTAXzTgtetOSNCAA53TE2CaiPink1tm1ZhzhSlc6a3tm41tTAXzTgtetOSNCAA53TE2Cai
• neuronal cytoplasmic inclusions_Park2<tm1Shn>/Park2<tm1Shn>,Slc6a3<tm4.1(tTA)Xz>/?,Tg(tetO-SNCA*A53T)E2Cai/?
  http://metadb.riken.jp/0011975I129S4SvJaeSor129S6SvEvTacC57BL6Park2tm1ShnPark2tm1ShnSlc6a3tm41tTAXzTgtetOSNCAA53TE2CaiPark2tm1ShnSlc6a3tm41tTAXzTgtetOSNCAA53TE2Cai
• neuronal cytoplasmic inclusions_Slc6a3<tm4.1(tTA)Xz>/Slc6a3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0011975I129S4SvJaeSor129S6SvEvTacC57BL6Slc6a3tm41tTAXzSlc6a3TgtetOSNCAA53TE2Cai0Slc6a3TgtetOSNCAA53TE2CaiSlc6a3tm41tTAXz