abnormal forebrain development_Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>

http://metadb.riken.jp/0003232I129SSvEvC57BL6C57BL6JCBANodaltm1RobNodalTgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcNodaltm1RobNodalTgif1tm1CawTgif2tm1Dwot

abnormal forebrain development_Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• TGFB-induced factor homeobox 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1915299
• TGFB-induced factor homeobox 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1194497
• transgene insertion 1, Andrew P McMahon
  http://metadb.riken.jp/db/mgi_rdf/MGI:2656537
• nodal
  http://metadb.riken.jp/db/mgi_rdf/MGI:97359

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Sox2-cre)1Amc|Nodal<tm1Rob>|Nodal<+>|Tgif1<tm1Caw>|Tgif2<tm1Dwot>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal forebrain development
  http://purl.obolibrary.org/obo/MP_0003232

文献

http://purl.org/net/cito/citesAsAuthority

• Kenichiro. Taniguchi, et.al., Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway., PLoS genetics, 2012, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/22383895