Kenichiro. Taniguchi, et.al., Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway., PLoS genetics, 2012, 8

http://rdf.ncbi.nlm.nih.gov/pubmed/22383895

Kenichiro. Taniguchi, et.al., Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway., PLoS genetics, 2012, 8

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal forebrain morphology_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0000783I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• abnormal forebrain development_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0003232I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• abnormal cephalic neural fold morphology_Gli3<tm1Alj>/Gli3<+>,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0011259I129S6SvEvTac129X1SvJC57BL6JCBAGli3tm1AljGli3Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1Amc0Tgif1tm1CawGli3Tgif2tm1DwotGli3tm1AljTgSox2cre1Amc
• decreased embryonic neuroepithelial cell proliferation_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0012706I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• decreased forebrain size_Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0012138I129SSvEvC57BL6C57BL6JCBANodaltm1RobNodalTgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcNodaltm1RobNodalTgif1tm1CawTgif2tm1Dwot
• rostral body truncation_Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0012157I129SSvEvC57BL6C57BL6JCBANodaltm1RobNodalTgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcNodaltm1RobNodalTgif1tm1CawTgif2tm1Dwot
• abnormal forebrain development_Gli3<tm1Alj>/Gli3<+>,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0003232I129S6SvEvTac129X1SvJC57BL6JCBAGli3tm1AljGli3Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1Amc0Tgif1tm1CawGli3Tgif2tm1DwotGli3tm1AljTgSox2cre1Amc
• abnormal forebrain development_Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0003232I129SSvEvC57BL6C57BL6JCBANodaltm1RobNodalTgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcNodaltm1RobNodalTgif1tm1CawTgif2tm1Dwot
• increased apoptosis_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0006042I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• abnormal embryonic neuroepithelium morphology_Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0004261I129SSvEvC57BL6C57BL6JCBANodaltm1RobNodalTgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcNodaltm1RobNodalTgif1tm1CawTgif2tm1Dwot
• heterotaxia_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0004133I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• abnormal olfactory epithelium morphology_Gli3<tm1Alj>/Gli3<+>,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0008789I129S6SvEvTac129X1SvJC57BL6JCBAGli3tm1AljGli3Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1Amc0Tgif1tm1CawGli3Tgif2tm1DwotGli3tm1AljTgSox2cre1Amc
• decreased embryonic neuroepithelial cell proliferation_Gli3<tm1Alj>/Gli3<+>,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0012706I129S6SvEvTac129X1SvJC57BL6JCBAGli3tm1AljGli3Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1Amc0Tgif1tm1CawGli3Tgif2tm1DwotGli3tm1AljTgSox2cre1Amc
• abnormal cephalic neural fold morphology_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0011259I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• embryonic growth retardation_Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0003984I129SSvEvC57BL6C57BL6JCBANodaltm1RobNodalTgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcNodaltm1RobNodalTgif1tm1CawTgif2tm1Dwot
• embryonic growth retardation_Nodal<tm1Rob>/Nodal<+>,Smad2<tm1.1Epb>/Smad2<+>
  http://metadb.riken.jp/0003984I129SSvEv129X1SvJC57BL6JSJLNodaltm1RobNodalSmad2tm11EpbSmad2Smad2tm11EpbNodalNodaltm1RobSmad2
• abnormal olfactory epithelium morphology_Nodal<tm1Rob>/Nodal<+>,Smad2<tm1.1Epb>/Smad2<+>
  http://metadb.riken.jp/0008789I129SSvEv129X1SvJC57BL6JSJLNodaltm1RobNodalSmad2tm11EpbSmad2Smad2tm11EpbNodalNodaltm1RobSmad2
• embryonic lethality during organogenesis, incomplete penetrance_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0011108I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• abnormal eye development_Nodal<tm1Rob>/Nodal<+>,Smad2<tm1.1Epb>/Smad2<+>
  http://metadb.riken.jp/0001286I129SSvEv129X1SvJC57BL6JSJLNodaltm1RobNodalSmad2tm11EpbSmad2Smad2tm11EpbNodalNodaltm1RobSmad2
• proboscis_Nodal<tm1Rob>/Nodal<+>,Smad2<tm1.1Epb>/Smad2<+>
  http://metadb.riken.jp/0006290I129SSvEv129X1SvJC57BL6JSJLNodaltm1RobNodalSmad2tm11EpbSmad2Smad2tm11EpbNodalNodaltm1RobSmad2
• proboscis_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0006290I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• cyclopia_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0005163I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• decreased forebrain size_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0012138I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• abnormal olfactory epithelium morphology_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0008789I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• holoprosencephaly_Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0005157I129SSvEvC57BL6C57BL6JCBANodaltm1RobNodalTgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcNodaltm1RobNodalTgif1tm1CawTgif2tm1Dwot
• incomplete rostral neuropore closure_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0000928I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• abnormal optic vesicle formation_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0003425I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• holoprosencephaly_Nodal<tm1Rob>/Nodal<+>,Smad2<tm1.1Epb>/Smad2<+>
  http://metadb.riken.jp/0005157I129SSvEv129X1SvJC57BL6JSJLNodaltm1RobNodalSmad2tm11EpbSmad2Smad2tm11EpbNodalNodaltm1RobSmad2
• exencephaly_Gli3<tm1Alj>/Gli3<+>,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000914I129S6SvEvTac129X1SvJC57BL6JCBAGli3tm1AljGli3Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1Amc0Tgif1tm1CawGli3Tgif2tm1DwotGli3tm1AljTgSox2cre1Amc
• decreased embryonic neuroepithelium thickness_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0012703I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot