increased hepatocellular carcinoma incidence_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<+>

http://metadb.riken.jp/0003331I129C57BL6Stk3tm11JavStk3tm11JavStk4GtAJ0315WtsiStk4Stk4GtAJ0315WtsiStk4Stk3tm11Jav

increased hepatocellular carcinoma incidence_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• serine/threonine kinase 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:1928487
• serine/threonine kinase 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:1929004

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Stk4<Gt(AJ0315)Wtsi>|Stk4<+>|Stk3<tm1.1Jav>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased hepatocellular carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0003331

文献

http://purl.org/net/cito/citesAsAuthority

• Dawang. Zhou, et.al., Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene., Cancer cell, 2009, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/19878874