Dawang. Zhou, et.al., Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene., Cancer cell, 2009, 16

http://rdf.ncbi.nlm.nih.gov/pubmed/19878874

Dawang. Zhou, et.al., Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene., Cancer cell, 2009, 16

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Stk3<tm1Jav>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4410615
• Stk3<tm1.1Jav>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4410616

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased hepatocellular carcinoma incidence_Stk3<tm1.1Jav>/Stk3<+>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0003331I129C57BL6Stk3tm11JavStk3Stk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11JavStk3
• decreased sensitivity to induced cell death_Stk3<tm1.1Jav>/Stk3<tm1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0008944I129C57BL6Stk3tm11JavStk3tm1JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11JavStk3tm1Jav
• abnormal vitelline vasculature morphology_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0003229I129C57BL6Stk3tm11JavStk3tm11JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11Jav
• embryonic growth retardation_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0003984I129C57BL6Stk3tm11JavStk3tm11JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11Jav
• increased hepatocellular carcinoma incidence_Stk3<tm1.1Jav>/Stk3<tm1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0003331I129C57BL6Stk3tm11JavStk3tm1JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11JavStk3tm1Jav
• liver hyperplasia_Stk3<tm1Jav>/Stk3<tm1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005141I129C57BL6Stk3tm1JavStk3tm1JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiTgAlbcre21Mgn0Stk4GtAJ0315WtsiTgAlbcre21MgnStk3tm1Jav
• embryonic lethality during organogenesis, complete penetrance_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0011098I129C57BL6Stk3tm11JavStk3tm11JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11Jav
• increased hepatocellular carcinoma incidence_Stk3<tm1Jav>/Stk3<tm1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003331I129C57BL6Stk3tm1JavStk3tm1JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiTgAlbcre21Mgn0Stk4GtAJ0315WtsiTgAlbcre21MgnStk3tm1Jav
• pale yolk sac_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0001722I129C57BL6Stk3tm11JavStk3tm11JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11Jav
• failure of initiation of embryo turning_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0004180I129C57BL6Stk3tm11JavStk3tm11JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11Jav
• increased hepatocellular carcinoma incidence_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<+>
  http://metadb.riken.jp/0003331I129C57BL6Stk3tm11JavStk3tm11JavStk4GtAJ0315WtsiStk4Stk4GtAJ0315WtsiStk4Stk3tm11Jav
• increased hepatocellular carcinoma incidence_Stk3<tm1Jav>/Stk3<tm1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0003331I129C57BL6Stk3tm1JavStk3tm1JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm1JavStk4GtAJ0315Wtsi
• increased hepatocyte proliferation_Stk3<tm1.1Jav>/Stk3<tm1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0003893I129C57BL6Stk3tm11JavStk3tm1JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11JavStk3tm1Jav
• liver hyperplasia_Stk3<tm1.1Jav>/Stk3<tm1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0005141I129C57BL6Stk3tm11JavStk3tm1JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11JavStk3tm1Jav
• lethargy_Stk3<tm1.1Jav>/Stk3<+>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0005202I129C57BL6Stk3tm11JavStk3Stk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11JavStk3
• enlarged pericardium_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0000291I129C57BL6Stk3tm11JavStk3tm11JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11Jav
• decreased embryo size_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0001698I129C57BL6Stk3tm11JavStk3tm11JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11Jav
• liver hyperplasia_Stk3<tm1.1Jav>/Stk3<+>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0005141I129C57BL6Stk3tm11JavStk3Stk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11JavStk3
• liver hyperplasia_Stk3<tm1Jav>/Stk3<tm1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0005141I129C57BL6Stk3tm1JavStk3tm1JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm1JavStk4GtAJ0315Wtsi
• open neural tube_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0000929I129C57BL6Stk3tm11JavStk3tm11JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm11Jav
• increased hepatocyte proliferation_Stk3<tm1Jav>/Stk3<tm1Jav>,Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0003893I129C57BL6Stk3tm1JavStk3tm1JavStk4GtAJ0315WtsiStk4GtAJ0315WtsiStk3tm1JavStk4GtAJ0315Wtsi
• increased histiocytic sarcoma incidence_Stk4<Gt(AJ0315)Wtsi>/Stk4<Gt(AJ0315)Wtsi>
  http://metadb.riken.jp/0009321I129C57BL6Stk4GtAJ0315WtsiStk4GtAJ0315WtsiStk4GtAJ0315Wtsi
• increased mammary gland tumor incidence_Stk3<tm1.1Jav>/Stk3<tm1.1Jav>
  http://metadb.riken.jp/0010299I129C57BL6Stk3tm11JavStk3tm11JavStk3tm11Jav

class

http://purl.org/net/cito/citesAsAuthority

• Stk3<tm1Jav>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4410615
• Stk3<tm1.1Jav>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4410616