liver fibrosis_Col1a1<tm3(tetO-Fosl1,-DsRed)Wag>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

http://metadb.riken.jp/0003333I129S4SvJaeC57BL6Col1a1tm3tetOFosl1DsRedWagCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm3tetOFosl1DsRedWag

liver fibrosis_Col1a1<tm3(tetO-Fosl1,-DsRed)Wag>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Col1a1<tm3(tetO-Fosl1,-DsRed)Wag>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Col1a1<+>|Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>|Gt(ROSA)26Sor<+>|Col1a1<tm3(tetO-Fosl1,-DsRed)Wag>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• liver fibrosis
  http://purl.obolibrary.org/obo/MP_0003333

文献

http://purl.org/net/cito/citesAsAuthority

• Sebastian C. Hasenfuss, et.al., Activator Protein 1 transcription factor Fos-related antigen 1 (Fra-1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism., Hepatology (Baltimore, Md.), 2014, 59
  http://rdf.ncbi.nlm.nih.gov/pubmed/23703832