decreased pancreatic beta cell number_Nkx6-1<tm1.1Msan>/Nkx6-1<+>,Pdx1<tm1Cvw>/Pdx1<+>,Tg(Neurog3-cre)C1Able/0

http://metadb.riken.jp/0003339I129SvC57BL6SJLNkx61tm11MsanNkx61Pdx1tm1CvwPdx1TgNeurog3creC1Able0Pdx1Nkx61tm11MsanNkx61TgNeurog3creC1AblePdx1tm1Cvw

decreased pancreatic beta cell number_Nkx6-1<tm1.1Msan>/Nkx6-1<+>,Pdx1<tm1Cvw>/Pdx1<+>,Tg(Neurog3-cre)C1Able/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion C1, Andrew B Leiter
  http://metadb.riken.jp/db/mgi_rdf/MGI:3052640
• pancreatic and duodenal homeobox 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:102851
• NK6 homeobox 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1206039

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nkx6-1<tm1.1Msan>/Nkx6-1<+>,Pdx1<tm1Cvw>/Pdx1<+>,Tg(Neurog3-cre)C1Able/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pdx1<+>|Nkx6-1<tm1.1Msan>|Nkx6-1<+>|Tg(Neurog3-cre)C1Able|Pdx1<tm1Cvw>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased pancreatic beta cell number
  http://purl.obolibrary.org/obo/MP_0003339

文献

http://purl.org/net/cito/citesAsAuthority

• Ashleigh E. Schaffer, et.al., Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity., PLoS genetics, 2013, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/23382704