Ashleigh E. Schaffer, et.al., Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity., PLoS genetics, 2013, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/23382704

Ashleigh E. Schaffer, et.al., Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity., PLoS genetics, 2013, 9

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Nkx6-1<tm1.1Msan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5501129
• Nkx6-1<tm1.2Msan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5501147

class

http://purl.org/net/cito/citesAsAuthority

• Nkx6-1<tm1.1Msan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5501129
• Nkx6-1<tm1.2Msan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5501147

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• forelimb paralysis_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.2Msan>
  http://metadb.riken.jp/0000756I129S6SvEvTacC57BLDBASJLNkx61tm1JlrNkx61tm12MsanNkx61tm1JlrNkx61tm12Msan
• dehydration_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0001429I129SvC57BL6SJLNkx61tm1JlrNkx61tm11MsanTgCAGBgeoGFP21Lbe0TgNeurog3creC1Able0TgCAGBgeoGFP21LbeTgNeurog3creC1AbleNkx61tm1JlrNkx61tm11Msan
• hyperglycemia_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0001559I129SvC57BL6SJLNkx61tm1JlrNkx61tm11MsanTgCAGBgeoGFP21Lbe0TgNeurog3creC1Able0TgCAGBgeoGFP21LbeTgNeurog3creC1AbleNkx61tm1JlrNkx61tm11Msan
• decreased pancreatic beta cell number_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0003339I129C57BL6DBASJLNkx61tm1JlrNkx61tm11MsanGtROSA26Sortm1EYFPCosGtROSA26SorTgIns2cre25Mgn0Nkx61tm1JlrGtROSA26Sortm1EYFPCosNkx61tm11MsanTgIns2cre25MgnGtROSA26Sor
• decreased pancreatic beta cell number_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.2Msan>
  http://metadb.riken.jp/0003339I129S6SvEvTacC57BLDBASJLNkx61tm1JlrNkx61tm12MsanNkx61tm1JlrNkx61tm12Msan
• decreased pancreatic beta cell number_Nkx6-1<tm1.1Msan>/Nkx6-1<+>,Pdx1<tm1Cvw>/Pdx1<+>,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0003339I129SvC57BL6SJLNkx61tm11MsanNkx61Pdx1tm1CvwPdx1TgNeurog3creC1Able0Pdx1Nkx61tm11MsanNkx61TgNeurog3creC1AblePdx1tm1Cvw
他15件を見る
• decreased pancreatic beta cell number_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0003339I129SvC57BL6SJLNkx61tm1JlrNkx61tm11MsanTgCAGBgeoGFP21Lbe0TgNeurog3creC1Able0TgCAGBgeoGFP21LbeTgNeurog3creC1AbleNkx61tm1JlrNkx61tm11Msan
• increased pancreatic beta cell number_Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0003645IBALBcC57BL6TgCAGBgeoNkx61EGFPMsan0TgNeurog3creC1Able0TgCAGBgeoNkx61EGFPMsanTgNeurog3creC1Able
• abnormal pancreatic islet morphology_Nkx6-1<tm1.1Msan>/Nkx6-1<+>,Pdx1<tm1Cvw>/Pdx1<+>,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0005215I129SvC57BL6SJLNkx61tm11MsanNkx61Pdx1tm1CvwPdx1TgNeurog3creC1Able0Pdx1Nkx61tm11MsanNkx61TgNeurog3creC1AblePdx1tm1Cvw
• abnormal pancreatic beta cell differentiation_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0009175I129C57BL6DBASJLNkx61tm1JlrNkx61tm11MsanGtROSA26Sortm1EYFPCosGtROSA26SorTgIns2cre25Mgn0Nkx61tm1JlrGtROSA26Sortm1EYFPCosNkx61tm11MsanTgIns2cre25MgnGtROSA26Sor
• abnormal pancreatic beta cell differentiation_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0009175I129SvC57BL6SJLNkx61tm1JlrNkx61tm11MsanTgCAGBgeoGFP21Lbe0TgNeurog3creC1Able0TgCAGBgeoGFP21LbeTgNeurog3creC1AbleNkx61tm1JlrNkx61tm11Msan
• increased pancreatic alpha cell number_Nkx6-1<tm1.1Msan>/Nkx6-1<+>,Pdx1<tm1Cvw>/Pdx1<+>,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0009176I129SvC57BL6SJLNkx61tm11MsanNkx61Pdx1tm1CvwPdx1TgNeurog3creC1Able0Pdx1Nkx61tm11MsanNkx61TgNeurog3creC1AblePdx1tm1Cvw
• increased pancreatic alpha cell number_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0009176I129SvC57BL6SJLNkx61tm1JlrNkx61tm11MsanTgCAGBgeoGFP21Lbe0TgNeurog3creC1Able0TgCAGBgeoGFP21LbeTgNeurog3creC1AbleNkx61tm1JlrNkx61tm11Msan
• decreased pancreatic alpha cell number_Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0009177IBALBcC57BL6TgCAGBgeoNkx61EGFPMsan0TgNeurog3creC1Able0TgCAGBgeoNkx61EGFPMsanTgNeurog3creC1Able
• increased pancreatic delta cell number_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0009180I129C57BL6DBASJLNkx61tm1JlrNkx61tm11MsanGtROSA26Sortm1EYFPCosGtROSA26SorTgIns2cre25Mgn0Nkx61tm1JlrGtROSA26Sortm1EYFPCosNkx61tm11MsanTgIns2cre25MgnGtROSA26Sor
• increased pancreatic delta cell number_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0009180I129SvC57BL6SJLNkx61tm1JlrNkx61tm11MsanTgCAGBgeoGFP21Lbe0TgNeurog3creC1Able0TgCAGBgeoGFP21LbeTgNeurog3creC1AbleNkx61tm1JlrNkx61tm11Msan
• decreased pancreatic delta cell number_Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0009181IBALBcC57BL6TgCAGBgeoNkx61EGFPMsan0TgNeurog3creC1Able0TgCAGBgeoNkx61EGFPMsanTgNeurog3creC1Able
• increased pancreatic epsilon cell number_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0009190I129SvC57BL6SJLNkx61tm1JlrNkx61tm11MsanTgCAGBgeoGFP21Lbe0TgNeurog3creC1Able0TgCAGBgeoGFP21LbeTgNeurog3creC1AbleNkx61tm1JlrNkx61tm11Msan
• decreased pancreatic epsilon cell number_Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0009191IBALBcC57BL6TgCAGBgeoNkx61EGFPMsan0TgNeurog3creC1Able0TgCAGBgeoNkx61EGFPMsanTgNeurog3creC1Able
• postnatal lethality, complete penetrance_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
  http://metadb.riken.jp/0011085I129SvC57BL6SJLNkx61tm1JlrNkx61tm11MsanTgCAGBgeoGFP21Lbe0TgNeurog3creC1Able0TgCAGBgeoGFP21LbeTgNeurog3creC1AbleNkx61tm1JlrNkx61tm11Msan
• neonatal lethality, complete penetrance_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.2Msan>
  http://metadb.riken.jp/0011087I129S6SvEvTacC57BLDBASJLNkx61tm1JlrNkx61tm12MsanNkx61tm1JlrNkx61tm12Msan