decreased pancreatic beta cell number_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0

http://metadb.riken.jp/0003339I129SvC57BL6SJLNkx61tm1JlrNkx61tm11MsanTgCAGBgeoGFP21Lbe0TgNeurog3creC1Able0TgCAGBgeoGFP21LbeTgNeurog3creC1AbleNkx61tm1JlrNkx61tm11Msan

decreased pancreatic beta cell number_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• NK6 homeobox 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1206039
• transgene insertion C1, Andrew B Leiter
  http://metadb.riken.jp/db/mgi_rdf/MGI:3052640
• transgene insertion 21, Corrinne Lobe
  http://metadb.riken.jp/db/mgi_rdf/MGI:3046175

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(CAG-Bgeo/GFP)21Lbe|Tg(Neurog3-cre)C1Able|Nkx6-1<tm1Jlr>|Nkx6-1<tm1.1Msan>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased pancreatic beta cell number
  http://purl.obolibrary.org/obo/MP_0003339

文献

http://purl.org/net/cito/citesAsAuthority

• Ashleigh E. Schaffer, et.al., Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity., PLoS genetics, 2013, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/23382704