decreased pancreatic beta cell number_Dnmt3a<tm1Jae>/Dnmt3a<tm1Jae>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0

http://metadb.riken.jp/0003339IBlackSwissC57BL6CBAJSJLDnmt3atm1JaeDnmt3atm1JaeNkx22tm21SussNkx22tm21SussTgIns2cre23Herr0TgIns2cre23HerrNkx22tm21SussDnmt3atm1Jae

decreased pancreatic beta cell number_Dnmt3a<tm1Jae>/Dnmt3a<tm1Jae>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• NK2 homeobox 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97347
• transgene insertion 23, Pedro Luis Herrera
  http://metadb.riken.jp/db/mgi_rdf/MGI:4431238
• DNA methyltransferase 3A
  http://metadb.riken.jp/db/mgi_rdf/MGI:1261827

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Dnmt3a<tm1Jae>/Dnmt3a<tm1Jae>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Ins2-cre)23Herr|Nkx2-2<tm2.1Suss>|Dnmt3a<tm1Jae>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: Black Swiss * C57BL/6 * CBA/J * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased pancreatic beta cell number
  http://purl.obolibrary.org/obo/MP_0003339

文献

http://purl.org/net/cito/citesAsAuthority

• James B. Papizan, et.al., Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming., Genes & development, 2011, 25
  http://rdf.ncbi.nlm.nih.gov/pubmed/22056672