James B. Papizan, et.al., Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming., Genes & development, 2011, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/22056672

James B. Papizan, et.al., Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming., Genes & development, 2011, 25

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5297810

class

http://purl.org/net/cito/citesAsAuthority

• Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5297810

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hyperglycemia_Arx<tm1Gldn>/Arx<tm1Gldn>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0001559I129BlackSwissC57BL6CBAJSJLArxtm1GldnArxtm1GldnNkx22tm21SussNkx22tm21SussTgIns2cre23Herr0Arxtm1GldnTgIns2cre23HerrNkx22tm21Suss
• hyperglycemia_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/0001559I129S6SvEvTacBlackSwissC57BL6C57BL6JSJLNkx22tm21SussNkx22tm21SussNkx22tm21Suss
• reduced male fertility_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/0001922I129S6SvEvTacBlackSwissC57BL6C57BL6JSJLNkx22tm21SussNkx22tm21SussNkx22tm21Suss
• reduced female fertility_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/0001923I129S6SvEvTacBlackSwissC57BL6C57BL6JSJLNkx22tm21SussNkx22tm21SussNkx22tm21Suss
• premature death_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/0002083I129S6SvEvTacBlackSwissC57BL6C57BL6JSJLNkx22tm21SussNkx22tm21SussNkx22tm21Suss
• decreased pancreatic beta cell number_Arx<tm1Gldn>/Arx<tm1Gldn>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003339I129BlackSwissC57BL6CBAJSJLArxtm1GldnArxtm1GldnNkx22tm21SussNkx22tm21SussTgIns2cre23Herr0Arxtm1GldnTgIns2cre23HerrNkx22tm21Suss
他10件を見る
• decreased pancreatic beta cell number_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/0003339I129S6SvEvTacBlackSwissC57BL6C57BL6JSJLNkx22tm21SussNkx22tm21SussNkx22tm21Suss
• decreased pancreatic beta cell number_Dnmt3a<tm1Jae>/Dnmt3a<tm1Jae>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003339IBlackSwissC57BL6CBAJSJLDnmt3atm1JaeDnmt3atm1JaeNkx22tm21SussNkx22tm21SussTgIns2cre23Herr0TgIns2cre23HerrNkx22tm21SussDnmt3atm1Jae
• small pancreatic islets_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/0009172I129S6SvEvTacBlackSwissC57BL6C57BL6JSJLNkx22tm21SussNkx22tm21SussNkx22tm21Suss
• abnormal pancreatic beta cell differentiation_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009175I129S6SvEvTacBlackSwissC57BL6CBAJSJLNkx22tm21SussNkx22tm21SussGtROSA26Sortm14CAGtdTomatoHzeGtROSA26SorTgIns2cre23Herr0Nkx22tm21SussGtROSA26Sortm14CAGtdTomatoHzeGtROSA26SorTgIns2cre23Herr
• abnormal pancreatic beta cell differentiation_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>/Gt(ROSA)26Sor<+>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0009175I129S6SvEvTacBlackSwissC57BL6CBASJLNkx22tm21SussNkx22tm21SussGtROSA26Sortm14CAGtdTomatoHzeGtROSA26SorTgPdx1creEsr1Dam0Nkx22tm21SussTgPdx1creEsr1DamGtROSA26Sortm14CAGtdTomatoHzeGtROSA26Sor
• abnormal pancreatic beta cell differentiation_Dnmt3a<tm1Jae>/Dnmt3a<tm1Jae>,Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009175I129SSvBlackSwissC57BL6CBAJSJLDnmt3atm1JaeDnmt3atm1JaeGtROSA26Sortm1SorGtROSA26SorNkx22tm21SussNkx22tm21SussTgIns2cre23Herr0Nkx22tm21SussGtROSA26Sortm1SorDnmt3atm1JaeGtROSA26SorTgIns2cre23Herr
• increased pancreatic alpha cell number_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/0009176I129S6SvEvTacBlackSwissC57BL6C57BL6JSJLNkx22tm21SussNkx22tm21SussNkx22tm21Suss
• increased pancreatic alpha cell number_Dnmt3a<tm1Jae>/Dnmt3a<tm1Jae>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009176IBlackSwissC57BL6CBAJSJLDnmt3atm1JaeDnmt3atm1JaeNkx22tm21SussNkx22tm21SussTgIns2cre23Herr0TgIns2cre23HerrNkx22tm21SussDnmt3atm1Jae
• increased pancreatic epsilon cell number_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/0009190I129S6SvEvTacBlackSwissC57BL6C57BL6JSJLNkx22tm21SussNkx22tm21SussNkx22tm21Suss
• disorganized pancreatic islets_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>
  http://metadb.riken.jp/0009254I129S6SvEvTacBlackSwissC57BL6C57BL6JSJLNkx22tm21SussNkx22tm21SussNkx22tm21Suss