decreased cardiac output_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0

http://metadb.riken.jp/0003393B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds

decreased cardiac output_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 2182, Michael D Schneider
  http://metadb.riken.jp/db/mgi_rdf/MGI:2447636
• histone cell cycle regulator
  http://metadb.riken.jp/db/mgi_rdf/MGI:99430

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>|Hira<tm1c(EUCOMM)Wtsi>|Gt(ROSA)26Sor<+>|Hira<tm1d(EUCOMM)Wtsi>|Tg(Myh6-cre)2182Mds

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• B6.Cg-Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze> Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi> Tg(Myh6-cre)2182Mds

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased cardiac output
  http://purl.obolibrary.org/obo/MP_0003393

文献

http://purl.org/net/cito/citesAsAuthority

• Nicolas. Valenzuela, et.al., Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis., Disease models & mechanisms, 2016, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/26935106