Nicolas. Valenzuela, et.al., Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis., Disease models & mechanisms, 2016, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/26935106

Nicolas. Valenzuela, et.al., Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis., Disease models & mechanisms, 2016, 9

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hira<tm1d(EUCOMM)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5823078

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cardiac muscle contractility_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002972B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• cardiac fibrosis_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003141B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• myocardial fiber degeneration_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0004566B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• oxidative stress_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003674B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• congestive heart failure_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0006138B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• abnormal myocardial fiber physiology_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0004215B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• abnormal heart morphology_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000266B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• abnormal cardiovascular system physiology_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001544B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• abnormal blood circulation_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002128B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• abnormal sarcolemma morphology_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0004121B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• abnormal myocardial fiber morphology_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000278B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• decreased cardiac stroke volume_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011952B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds
• decreased cardiac output_Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze>/Gt(ROSA)26Sor<+>,Hira<tm1c(EUCOMM)Wtsi>/Hira<tm1d(EUCOMM)Wtsi>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003393B6CgGtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182MdsGtROSA26Sortm3CAGEYFPHzeGtROSA26SorHiratm1cEUCOMMWtsiHiratm1dEUCOMMWtsiTgMyh6cre2182Mds0GtROSA26Sortm3CAGEYFPHzeHiratm1cEUCOMMWtsiGtROSA26SorHiratm1dEUCOMMWtsiTgMyh6cre2182Mds

class

http://purl.org/net/cito/citesAsAuthority

• Hira<tm1d(EUCOMM)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5823078