decreased tumor growth/size_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>

http://metadb.riken.jp/0003447I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasPggt1btm1MbrgPggt1btm11MbrgPggt1btm1MbrgPggt1btm11MbrgFntbtm11MbrgFntbtm12MbrgKrastm4TyjKras

decreased tumor growth/size_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein geranylgeranyltransferase type I, beta subunit
  http://metadb.riken.jp/db/mgi_rdf/MGI:1917514
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• farnesyltransferase, CAAX box, beta
  http://metadb.riken.jp/db/mgi_rdf/MGI:1861305

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pggt1b<tm1Mbrg>|Pggt1b<tm1.1Mbrg>|Fntb<tm1.1Mbrg>|Fntb<tm1.2Mbrg>|Kras<tm4Tyj>|Kras<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased tumor growth/size
  http://purl.obolibrary.org/obo/MP_0003447

文献

http://purl.org/net/cito/citesAsAuthority

• Meng. Liu, et.al., Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20308544