Meng. Liu, et.al., Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

http://rdf.ncbi.nlm.nih.gov/pubmed/20308544

Meng. Liu, et.al., Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Fntb<tm1.1Mbrg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4441481
• Fntb<tm1.2Mbrg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4441483

class

http://purl.org/net/cito/citesAsAuthority

• Fntb<tm1.1Mbrg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4441481
• Fntb<tm1.2Mbrg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4441483

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cell cycle_Fntb<tm1.1Mbrg>/Fntb<tm1.1Mbrg>
  http://metadb.riken.jp/0003077I129P2OlaHsdC57BL6Fntbtm11MbrgFntbtm11MbrgFntbtm11Mbrg
• premature death_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasLyz2tm1creIfoLyz2Fntbtm11MbrgFntbtm12MbrgKrasKrastm4TyjLyz2tm1creIfoLyz2
• increased lung adenoma incidence_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>
  http://metadb.riken.jp/0002048I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasPggt1btm1MbrgPggt1btm11MbrgPggt1btm1MbrgPggt1btm11MbrgFntbtm11MbrgFntbtm12MbrgKrastm4TyjKras
• increased lung weight_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0005630I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasLyz2tm1creIfoLyz2Fntbtm11MbrgFntbtm12MbrgKrasKrastm4TyjLyz2tm1creIfoLyz2
• increased lung tumor incidence_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008014I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasPggt1btm1MbrgPggt1btm11MbrgLyz2tm1creIfoLyz2Pggt1btm1MbrgLyz2tm1creIfoLyz2Pggt1btm11MbrgFntbtm12MbrgFntbtm11MbrgKrasKrastm4Tyj
• abnormal cell cycle_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>
  http://metadb.riken.jp/0003077I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasFntbtm11MbrgFntbtm12MbrgKrasKrastm4Tyj
• increased lung carcinoma incidence_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>
  http://metadb.riken.jp/0008714I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasPggt1btm1MbrgPggt1btm11MbrgPggt1btm1MbrgPggt1btm11MbrgFntbtm11MbrgFntbtm12MbrgKrastm4TyjKras
• decreased fibroblast proliferation_Fntb<tm1.1Mbrg>/Fntb<tm1.1Mbrg>
  http://metadb.riken.jp/0011704I129P2OlaHsdC57BL6Fntbtm11MbrgFntbtm11MbrgFntbtm11Mbrg
• increased fibroblast apoptosis_Fntb<tm1.1Mbrg>/Fntb<tm1.1Mbrg>,Pggt1b<tm1Mbrg>/Pggt1b<tm1Mbrg>
  http://metadb.riken.jp/0013501I129P2OlaHsdC57BL6Fntbtm11MbrgFntbtm11MbrgPggt1btm1MbrgPggt1btm1MbrgPggt1btm1MbrgFntbtm11Mbrg
• increased lung weight_Kras<tm4Tyj>/Kras<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0005630I129P2OlaHsd129S4SvJaeKrastm4TyjKrasLyz2tm1creIfoLyz2KrasKrastm4TyjLyz2tm1creIfoLyz2
• increased lung tumor incidence_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008014I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasLyz2tm1creIfoLyz2Fntbtm11MbrgFntbtm12MbrgKrasKrastm4TyjLyz2tm1creIfoLyz2
• lung epithelium hyperplasia_Kras<tm4Tyj>/Kras<+>
  http://metadb.riken.jp/0010945I129S4SvJaeKrastm4TyjKrasKrasKrastm4Tyj
• decreased tumor growth/size_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0003447I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasPggt1btm1MbrgPggt1btm11MbrgLyz2tm1creIfoLyz2Pggt1btm1MbrgLyz2tm1creIfoLyz2Pggt1btm11MbrgFntbtm12MbrgFntbtm11MbrgKrasKrastm4Tyj
• postnatal lethality, complete penetrance_Kras<tm4Tyj>/Kras<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0011085I129P2OlaHsd129S4SvJaeKrastm4TyjKrasLyz2tm1creIfoLyz2KrasKrastm4TyjLyz2tm1creIfoLyz2
• abnormal cell morphology_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>
  http://metadb.riken.jp/0000358I129P2OlaHsdBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgFntbtm12MbrgFntbtm11Mbrg
• increased lung carcinoma incidence_Kras<tm4Tyj>/Kras<+>
  http://metadb.riken.jp/0008714I129S4SvJaeKrastm4TyjKrasKrasKrastm4Tyj
• abnormal lung epithelium morphology_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>
  http://metadb.riken.jp/0006382I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasPggt1btm1MbrgPggt1btm11MbrgPggt1btm1MbrgPggt1btm11MbrgFntbtm11MbrgFntbtm12MbrgKrastm4TyjKras
• increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>
  http://metadb.riken.jp/0008014I129S4SvJaeKrastm4TyjKrasKrasKrastm4Tyj
• decreased fibroblast proliferation_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>
  http://metadb.riken.jp/0011704I129P2OlaHsdBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgFntbtm12MbrgFntbtm11Mbrg
• increased lung tumor incidence_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>
  http://metadb.riken.jp/0008014I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasPggt1btm1MbrgPggt1btm11MbrgPggt1btm1MbrgPggt1btm11MbrgFntbtm11MbrgFntbtm12MbrgKrastm4TyjKras
• premature death_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasPggt1btm1MbrgPggt1btm11MbrgLyz2tm1creIfoLyz2Pggt1btm1MbrgLyz2tm1creIfoLyz2Pggt1btm11MbrgFntbtm12MbrgFntbtm11MbrgKrasKrastm4Tyj
• increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008014I129P2OlaHsd129S4SvJaeKrastm4TyjKrasLyz2tm1creIfoLyz2KrasKrastm4TyjLyz2tm1creIfoLyz2
• decreased tumor growth/size_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0003447I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasLyz2tm1creIfoLyz2Fntbtm11MbrgFntbtm12MbrgKrasKrastm4TyjLyz2tm1creIfoLyz2
• increased lung adenoma incidence_Kras<tm4Tyj>/Kras<+>
  http://metadb.riken.jp/0002048I129S4SvJaeKrastm4TyjKrasKrasKrastm4Tyj
• abnormal cell morphology_Fntb<tm1.1Mbrg>/Fntb<tm1.1Mbrg>
  http://metadb.riken.jp/0000358I129P2OlaHsdC57BL6Fntbtm11MbrgFntbtm11MbrgFntbtm11Mbrg
• abnormal cell cycle_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>
  http://metadb.riken.jp/0003077I129P2OlaHsdBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgFntbtm12MbrgFntbtm11Mbrg
• decreased tumor growth/size_Fntb<tm1.1Mbrg>/Fntb<tm1.2Mbrg>,Kras<tm4Tyj>/Kras<+>,Pggt1b<tm1Mbrg>/Pggt1b<tm1.1Mbrg>
  http://metadb.riken.jp/0003447I129P2OlaHsd129S4SvJaeBALBcJC57BL6FVBNFntbtm11MbrgFntbtm12MbrgKrastm4TyjKrasPggt1btm1MbrgPggt1btm11MbrgPggt1btm1MbrgPggt1btm11MbrgFntbtm11MbrgFntbtm12MbrgKrastm4TyjKras

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD09109
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD09109
• CD30433
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD30433