increased pancreatic beta cell number_Foxo1<tm1Whb>/Foxo1<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0

http://metadb.riken.jp/0003645I129S4SvJaeC57BL6JCBAJFoxo1tm1WhbFoxo1Pdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0Pdpk1tm1MakaFoxo1tm1WhbFoxo1TgIns2cre23Herr

increased pancreatic beta cell number_Foxo1<tm1Whb>/Foxo1<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• forkhead box O1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1890077
• transgene insertion 23, Pedro Luis Herrera
  http://metadb.riken.jp/db/mgi_rdf/MGI:4431238
• 3-phosphoinositide dependent protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1338068

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Foxo1<tm1Whb>/Foxo1<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pdpk1<tm1Maka>|Foxo1<tm1Whb>|Foxo1<+>|Tg(Ins2-cre)23Herr

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6J * CBA/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic beta cell number
  http://purl.obolibrary.org/obo/MP_0003645

文献

http://purl.org/net/cito/citesAsAuthority

• Naoko. Hashimoto, et.al., Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass., Nature genetics, 2006, 38
  http://rdf.ncbi.nlm.nih.gov/pubmed/16642023