Naoko. Hashimoto, et.al., Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass., Nature genetics, 2006, 38

http://rdf.ncbi.nlm.nih.gov/pubmed/16642023

Naoko. Hashimoto, et.al., Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass., Nature genetics, 2006, 38

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased circulating insulin level_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002727I129S4SvJaeC57BL6JCBAJPdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0TgIns2cre23HerrPdpk1tm1Maka
• decreased circulating glucose level_Foxo1<tm1Whb>/Foxo1<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005560I129S4SvJaeC57BL6JCBAJFoxo1tm1WhbFoxo1Pdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0Pdpk1tm1MakaFoxo1tm1WhbFoxo1TgIns2cre23Herr
• increased circulating insulin level_Foxo1<tm1Whb>/Foxo1<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002079I129S4SvJaeC57BL6JCBAJFoxo1tm1WhbFoxo1Pdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0Pdpk1tm1MakaFoxo1tm1WhbFoxo1TgIns2cre23Herr
• small pancreatic islets_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009172I129S4SvJaeC57BL6JCBAJPdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0TgIns2cre23HerrPdpk1tm1Maka
• abnormal pancreas physiology_Foxo1<tm1Whb>/Foxo1<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002693I129S4SvJaeC57BL6JCBAJFoxo1tm1WhbFoxo1Pdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0Pdpk1tm1MakaFoxo1tm1WhbFoxo1TgIns2cre23Herr
• abnormal pancreatic beta cell morphology_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005217I129S4SvJaeC57BL6JCBAJPdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0TgIns2cre23HerrPdpk1tm1Maka
• decreased body weight_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0001262I129S4SvJaeC57BL6JCBAJPdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0TgIns2cre23HerrPdpk1tm1Maka
• hyperglycemia_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0001559I129S4SvJaeC57BL6JCBAJPdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0TgIns2cre23HerrPdpk1tm1Maka
• increased circulating glucose level_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005559I129S4SvJaeC57BL6JCBAJPdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0TgIns2cre23HerrPdpk1tm1Maka
• abnormal pancreas physiology_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002693I129S4SvJaeC57BL6JCBAJPdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0TgIns2cre23HerrPdpk1tm1Maka
• increased pancreatic beta cell number_Foxo1<tm1Whb>/Foxo1<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003645I129S4SvJaeC57BL6JCBAJFoxo1tm1WhbFoxo1Pdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0Pdpk1tm1MakaFoxo1tm1WhbFoxo1TgIns2cre23Herr
• premature death_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6JCBAJPdpk1tm1MakaPdpk1tm1MakaTgIns2cre23Herr0TgIns2cre23HerrPdpk1tm1Maka