increased hemangiosarcoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>,Trp53<tm1Tyj>/Trp53<+>

http://metadb.riken.jp/0003667I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Trp53tm1TyjTrp53Trp53tm1TyjTrp53Suz12GtBetageo1KheNf1tm1TyjNf1Suz12

increased hemangiosarcoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>,Trp53<tm1Tyj>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• suppressor of zeste 12 homolog (Drosophila)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1261758
• neurofibromin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97306

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>,Trp53<tm1Tyj>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Tyj>|Trp53<+>|Suz12<Gt(Betageo)1Khe>|Nf1<tm1Tyj>|Nf1<+>|Suz12<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased hemangiosarcoma incidence
  http://purl.obolibrary.org/obo/MP_0003667

文献

http://purl.org/net/cito/citesAsAuthority

• Thomas. De Raedt, et.al., PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies., Nature, 2014, 514
  http://rdf.ncbi.nlm.nih.gov/pubmed/25119042