Thomas. De Raedt, et.al., PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies., Nature, 2014, 514

http://rdf.ncbi.nlm.nih.gov/pubmed/25119042

Thomas. De Raedt, et.al., PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies., Nature, 2014, 514

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased tumor incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0002020I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12
• increased tumor incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002020I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Trp53tm1TyjTrp53Trp53tm1TyjTrp53Suz12GtBetageo1KheNf1tm1TyjNf1Suz12
• increased tumor incidence_Nf1<tm1Tyj>/Nf1<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002020I129S2SvPasC57BL6Nf1tm1TyjNf1Trp53tm1TyjTrp53Nf1tm1TyjNf1Trp53tm1TyjTrp53
• increased neurofibrosarcoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0002030I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12
• increased neurofibrosarcoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002030I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Trp53tm1TyjTrp53Trp53tm1TyjTrp53Suz12GtBetageo1KheNf1tm1TyjNf1Suz12
• increased neurofibrosarcoma incidence_Nf1<tm1Tyj>/Nf1<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002030I129S2SvPasC57BL6Nf1tm1TyjNf1Trp53tm1TyjTrp53Nf1tm1TyjNf1Trp53tm1TyjTrp53
他19件を見る
• increased neuroblastoma incidence_Nf1<tm1Tyj>/Nf1<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002039I129S2SvPasC57BL6Nf1tm1TyjNf1Trp53tm1TyjTrp53Nf1tm1TyjNf1Trp53tm1TyjTrp53
• premature death_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12
• premature death_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Trp53tm1TyjTrp53Trp53tm1TyjTrp53Suz12GtBetageo1KheNf1tm1TyjNf1Suz12
• premature death_Nf1<tm1Tyj>/Nf1<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002083I129S2SvPasC57BL6Nf1tm1TyjNf1Trp53tm1TyjTrp53Nf1tm1TyjNf1Trp53tm1TyjTrp53
• increased intestinal adenoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0002404I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12
• abnormal melanocyte morphology_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0002877I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12
• increased hepatocellular carcinoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0003331I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12
• increased hemangiosarcoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0003667I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Trp53tm1TyjTrp53Trp53tm1TyjTrp53Suz12GtBetageo1KheNf1tm1TyjNf1Suz12
• increased histiocytic sarcoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0009321I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12
• increased histiocytic sarcoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009321I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Trp53tm1TyjTrp53Trp53tm1TyjTrp53Suz12GtBetageo1KheNf1tm1TyjNf1Suz12
• increased histiocytic sarcoma incidence_Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0009321I129P2OlaHsdSuz12GtBetageo1KheSuz12Suz12GtBetageo1KheSuz12
• increased histiocytic sarcoma incidence_Nf1<tm1Tyj>/Nf1<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009321I129S2SvPasC57BL6Nf1tm1TyjNf1Trp53tm1TyjTrp53Nf1tm1TyjNf1Trp53tm1TyjTrp53
• increased glioma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0010278I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Trp53tm1TyjTrp53Trp53tm1TyjTrp53Suz12GtBetageo1KheNf1tm1TyjNf1Suz12
• increased glioma incidence_Nf1<tm1Tyj>/Nf1<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0010278I129S2SvPasC57BL6Nf1tm1TyjNf1Trp53tm1TyjTrp53Nf1tm1TyjNf1Trp53tm1TyjTrp53
• increased Schwannoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0010310I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12
• increased neurofibroma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0010314I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12
• increased lymphoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>
  http://metadb.riken.jp/0012431I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12
• increased lymphoma incidence_Nf1<tm1Tyj>/Nf1<+>,Suz12<Gt(Betageo)1Khe>/Suz12<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0012431I129P2OlaHsd129S2SvPasC57BL6Nf1tm1TyjNf1Suz12GtBetageo1KheSuz12Trp53tm1TyjTrp53Trp53tm1TyjTrp53Suz12GtBetageo1KheNf1tm1TyjNf1Suz12
• increased lymphoma incidence_Nf1<tm1Tyj>/Nf1<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0012431I129S2SvPasC57BL6Nf1tm1TyjNf1Trp53tm1TyjTrp53Nf1tm1TyjNf1Trp53tm1TyjTrp53