increased tumor growth/size_Apc<Min>/Apc<+>,Col1a1<tm9(tetO-Dnmt3b_i1)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

http://metadb.riken.jp/0003721I129S4SvJaeC57BL6C57BL6JApcMinApcCol1a1tm9tetODnmt3bi1JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorApcCol1a1tm9tetODnmt3bi1JaeCol1a1GtROSA26Sortm1rtTAM2JaeApcMinGtROSA26Sor

increased tumor growth/size_Apc<Min>/Apc<+>,Col1a1<tm9(tetO-Dnmt3b_i1)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467
• adenomatosis polyposis coli
  http://metadb.riken.jp/db/mgi_rdf/MGI:88039

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Apc<Min>/Apc<+>,Col1a1<tm9(tetO-Dnmt3b_i1)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Apc<+>|Col1a1<tm9(tetO-Dnmt3b_i1)Jae>|Col1a1<+>|Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>|Apc<Min>|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased tumor growth/size
  http://purl.obolibrary.org/obo/MP_0003721

文献

http://purl.org/net/cito/citesAsAuthority

• Heinz G. Linhart, et.al., Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing., Genes & development, 2007, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/18056424