increased autoantibody level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0

http://metadb.riken.jp/0003725I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz

increased autoantibody level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• LYN proto-oncogene, Src family tyrosine kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96892
• transgene insertion 1-1, Boris Reizis
  http://metadb.riken.jp/db/mgi_rdf/MGI:3763247

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lyn<tm1.1Calo>|Tg(Itgax-cre)1-1Reiz

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased autoantibody level
  http://purl.obolibrary.org/obo/MP_0003725

文献

http://purl.org/net/cito/citesAsAuthority

• Chrystelle. Lamagna, et.al., Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110
  http://rdf.ncbi.nlm.nih.gov/pubmed/23940344