Chrystelle. Lamagna, et.al., Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

http://rdf.ncbi.nlm.nih.gov/pubmed/23940344

Chrystelle. Lamagna, et.al., Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lyn<tm1.1Calo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5545812

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased B cell number_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0005017I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• increased circulating interleukin-12 level_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0008617I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• lymph node hyperplasia_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008102I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased monocyte cell number_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0000220I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• premature death_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased autoantibody level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0003725I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased circulating interferon-gamma level_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0008577I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• lung inflammation_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0001861I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased circulating interleukin-6 level_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0008596I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• abnormal renal glomerulus morphology_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0005325I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• enlarged spleen_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased leukocyte cell number_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0000218I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased plasma cell number_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0008097I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• increased circulating interferon-gamma level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008577I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased circulating interleukin-17 level_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0008614I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• abnormal dendritic cell physiology_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0002376I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• abnormal renal glomerulus morphology_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0005325I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased activated T cell number_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0001829I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased circulating tumor necrosis factor level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008553I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased circulating interleukin-6 level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008596I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• abnormal circulating cytokine level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0010210I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased dendritic cell number_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008126I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased circulating interleukin-12 level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008617I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• abnormal circulating chemokine level_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0010209I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• increased inflammatory response_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0001846I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• glomerulonephritis_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0002743I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• skin inflammation_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0004947I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• abnormal dendritic cell physiology_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0002376I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• abnormal circulating chemokine level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0010209I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased T cell number_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0005015I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• myeloid hyperplasia_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0010373I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• skin lesions_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0001212I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased plasma cell number_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008097I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• abnormal T cell activation_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0001828I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased circulating interleukin-17 level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008614I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• abnormal leukocyte physiology_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0002442I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased granulocyte number_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0000322I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• glomerulonephritis_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0002743I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• abnormal circulating cytokine level_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0010210I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• enlarged lymph nodes_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0000702I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• liver inflammation_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0001860I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz
• increased autoantibody level_Lyn<tm1Sor>/Lyn<tm1Sor>
  http://metadb.riken.jp/0003725I129S4SvJaeSorLyntm1SorLyntm1SorLyntm1Sor
• increased circulating interleukin-1 beta level_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008641I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz

class

http://purl.org/net/cito/citesAsAuthority

• Lyn<tm1.1Calo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5545812