increased osteosarcoma incidence_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>

http://metadb.riken.jp/0003789I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjTgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn

increased osteosarcoma incidence_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• RB transcriptional corepressor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97874
• transgene insertion 1, Andrew P McMahon
  http://metadb.riken.jp/db/mgi_rdf/MGI:3689349

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Rb1<tm3Tyj>|Tg(Sp7-tTA,tetO-EGFP/cre)1Amc|Trp53<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased osteosarcoma incidence
  http://purl.obolibrary.org/obo/MP_0003789

文献

http://purl.org/net/cito/citesAsAuthority

• Carl R. Walkley, et.al., Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease., Genes & development, 2008, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/18559481