Carl R. Walkley, et.al., Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease., Genes & development, 2008, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/18559481

Carl R. Walkley, et.al., Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease., Genes & development, 2008, 22

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased osteosarcoma incidence_Rb1<tm3Tyj>/Rb1<+>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0003789I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1TgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53Trp53TgSp7tTAtetOEGFPcre1AmcRb1Rb1tm3TyjTrp53tm1Brn
• increased osteosarcoma incidence_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0003789I129129P2OlaHsdC57BL6JCD1FVBNTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgSp7tTAtetOEGFPcre1Amc
• increased metastatic potential_Rb1<tm3Tyj>/Rb1<+>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0001272I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1TgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53Trp53TgSp7tTAtetOEGFPcre1AmcRb1Rb1tm3TyjTrp53tm1Brn
• premature death_Rb1<tm3Tyj>/Rb1<+>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0002083I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1TgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53Trp53TgSp7tTAtetOEGFPcre1AmcRb1Rb1tm3TyjTrp53tm1Brn
• increased metastatic potential_Rb1<tm3Tyj>/Rb1<+>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0001272I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1TgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjRb1TgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• increased metastatic potential_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0001272I129129P2OlaHsdC57BL6JCD1FVBNTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgSp7tTAtetOEGFPcre1Amc
• increased metastatic potential_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0001272I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53Rb1tm3TyjTrp53TgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• increased osteosarcoma incidence_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0003789I129129P2OlaHsdC57BL6JCD1FVBNTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53Trp53tm1BrnTgSp7tTAtetOEGFPcre1AmcTrp53
• premature death_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002083I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjTgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• premature death_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0002083I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53Rb1tm3TyjTrp53TgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• increased osteosarcoma incidence_Rb1<tm3Tyj>/Rb1<+>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0003789I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1TgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjRb1TgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• increased tumor incidence_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002020I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjTgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• premature death_Rb1<tm3Tyj>/Rb1<+>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002083I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1TgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjRb1TgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• increased osteosarcoma incidence_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0003789I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53Rb1tm3TyjTrp53TgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• premature death_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002083I129129P2OlaHsdC57BL6JCD1FVBNTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgSp7tTAtetOEGFPcre1Amc
• postnatal growth retardation_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0001732I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjTgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• increased osteosarcoma incidence_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0003789I129129P2OlaHsdC57BL6JCD1FVBNRb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjTgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn