increased osteosarcoma incidence_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0

http://metadb.riken.jp/0003789I129129P2OlaHsdFVBNRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgCol1a1cre1Kry0Rb1tm2BrnTgCol1a1cre1KryTrp53tm1Brn

increased osteosarcoma incidence_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• RB transcriptional corepressor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97874
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 1, Gerard Karsenty
  http://metadb.riken.jp/db/mgi_rdf/MGI:3041865

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Rb1<tm2Brn>|Tg(Col1a1-cre)1Kry|Trp53<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased osteosarcoma incidence
  http://purl.obolibrary.org/obo/MP_0003789

文献

http://purl.org/net/cito/citesAsAuthority

• Yan. Chen, et.al., RANKL blockade prevents and treats aggressive osteosarcomas., Science translational medicine, 2015, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/26659571