increased osteosarcoma incidence_Tg(Bglap2-TAg)1Rkho/0,Tg(Col1a1-cre)1Kry/0,Tnfrsf11a<tm1.1Pngr>/Tnfrsf11a<tm1.1Pngr>

http://metadb.riken.jp/0003789I129P2OlaHsdC57BL6FVBNTgBglap2TAg1Rkho0TgCol1a1cre1Kry0Tnfrsf11atm11PngrTnfrsf11atm11PngrTgCol1a1cre1KryTgBglap2TAg1RkhoTnfrsf11atm11Pngr

increased osteosarcoma incidence_Tg(Bglap2-TAg)1Rkho/0,Tg(Col1a1-cre)1Kry/0,Tnfrsf11a<tm1.1Pngr>/Tnfrsf11a<tm1.1Pngr>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• tumor necrosis factor receptor superfamily, member 11a, NFKB activator
  http://metadb.riken.jp/db/mgi_rdf/MGI:1314891
• transgene insertion 1, Rama Khokha
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796021
• transgene insertion 1, Gerard Karsenty
  http://metadb.riken.jp/db/mgi_rdf/MGI:3041865

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(Bglap2-TAg)1Rkho/0,Tg(Col1a1-cre)1Kry/0,Tnfrsf11a<tm1.1Pngr>/Tnfrsf11a<tm1.1Pngr>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Col1a1-cre)1Kry|Tg(Bglap2-TAg)1Rkho|Tnfrsf11a<tm1.1Pngr>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased osteosarcoma incidence
  http://purl.obolibrary.org/obo/MP_0003789

文献

http://purl.org/net/cito/citesAsAuthority

• Yan. Chen, et.al., RANKL blockade prevents and treats aggressive osteosarcomas., Science translational medicine, 2015, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/26659571