increased hepatocyte apoptosis_Gpx4<tm1.1Qra>/Gpx4<tm1.1Qra>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>

http://metadb.riken.jp/0003887I129S1Sv129S6SvEvTac129X1SvJC57BL6SJLGpx4tm11QraGpx4tm11QraGtROSA26Sortm1creERTNatGtROSA26SorGtROSA26SorGtROSA26Sortm1creERTNatGpx4tm11Qra

increased hepatocyte apoptosis_Gpx4<tm1.1Qra>/Gpx4<tm1.1Qra>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• glutathione peroxidase 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:104767

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gpx4<tm1.1Qra>/Gpx4<tm1.1Qra>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Gt(ROSA)26Sor<tm1(cre/ERT)Nat>|Gpx4<tm1.1Qra>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased hepatocyte apoptosis
  http://purl.obolibrary.org/obo/MP_0003887

文献

http://purl.org/net/cito/citesAsAuthority

• Si-Eun. Yoo, et.al., Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain., Free radical biology & medicine, 2012, 52
  http://rdf.ncbi.nlm.nih.gov/pubmed/22401858