decreased thermal nociceptive threshold_Tph1<tm2Lex>/Tph1<tm2Lex>,Tph2<tm1Lex>/Tph2<tm1Lex>

http://metadb.riken.jp/0003998I129S5SvEvBrdC57BL6JTph1tm2LexTph1tm2LexTph2tm1LexTph2tm1LexTph1tm2LexTph2tm1Lex

decreased thermal nociceptive threshold_Tph1<tm2Lex>/Tph1<tm2Lex>,Tph2<tm1Lex>/Tph2<tm1Lex>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• tryptophan hydroxylase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:2651811
• tryptophan hydroxylase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:98796

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tph1<tm2Lex>/Tph1<tm2Lex>,Tph2<tm1Lex>/Tph2<tm1Lex>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tph1<tm2Lex>|Tph2<tm1Lex>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S5/SvEvBrd * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased thermal nociceptive threshold
  http://purl.obolibrary.org/obo/MP_0003998

文献

http://purl.org/net/cito/citesAsAuthority

• Katerina V. Savelieva, et.al., Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants., PloS one, 2008, 3
  http://rdf.ncbi.nlm.nih.gov/pubmed/18923670