insulitis_Cd80<tm1Shr>/Cd80<tm1Shr>,Cd86<tm2Shr>/Cd86<tm2Shr>,Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0

http://metadb.riken.jp/0004031I129S4SvJaeFVBNNODCd80tm1ShrCd80tm1ShrCd86tm2ShrCd86tm2ShrTgIghmCtla4IgCd801Jbs0Cd86tm2ShrCd80tm1ShrTgIghmCtla4IgCd801Jbs

insulitis_Cd80<tm1Shr>/Cd80<tm1Shr>,Cd86<tm2Shr>/Cd86<tm2Shr>,Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• CD86 antigen
  http://metadb.riken.jp/db/mgi_rdf/MGI:101773
• transgene insertion 1, Jeffery Bluestone
  http://metadb.riken.jp/db/mgi_rdf/MGI:3711770
• CD80 antigen
  http://metadb.riken.jp/db/mgi_rdf/MGI:101775

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cd80<tm1Shr>/Cd80<tm1Shr>,Cd86<tm2Shr>/Cd86<tm2Shr>,Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cd86<tm2Shr>|Cd80<tm1Shr>|Tg(Ighm-Ctla4Ig/Cd80)1Jbs

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * FVB/N * NOD

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• insulitis
  http://purl.obolibrary.org/obo/MP_0004031

文献

http://purl.org/net/cito/citesAsAuthority

• Brian T. Fife, et.al., Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist., The Journal of clinical investigation, 2006, 116
  http://rdf.ncbi.nlm.nih.gov/pubmed/16886063