increased squamous cell carcinoma incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0

http://metadb.riken.jp/0004207I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0TgKRT5E2F12Dgj0TgKRT5cre5132JljBrca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd

increased squamous cell carcinoma incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 2, David G Johnson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2677032
• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537
• transgene insertion 5132, Jose Luis Jorcano
  http://metadb.riken.jp/db/mgi_rdf/MGI:3050066

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(KRT5-cre)5132Jlj|Brca1<tm2Cxd>|Tg(KRT5-E2F1)2Dgj|Brca1<tm1Cxd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased squamous cell carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0004207

文献

http://purl.org/net/cito/citesAsAuthority

• Thomas R. Berton, et.al., Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues., Oncogene, 2003, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/12934101