Thomas R. Berton, et.al., Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues., Oncogene, 2003, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/12934101

Thomas R. Berton, et.al., Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues., Oncogene, 2003, 22

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased skin tumor incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0010300I129S6SvEvTacC57BL6Brca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0Brca1tm2CxdTgKRT5cre5132JljBrca1tm1Cxd
• increased keratinocyte proliferation_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0009583I129S6SvEvTacC57BL6Brca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0Brca1tm2CxdTgKRT5cre5132JljBrca1tm1Cxd
• increased skin tumor incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0010300I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0TgKRT5E2F12Dgj0TgKRT5cre5132JljBrca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased keratinocyte proliferation_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0009583I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5E2F12Dgj0Brca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased tumor incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0002020I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5E2F12Dgj0Brca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased tumor incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0002020I129S6SvEvTacC57BL6Brca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0Brca1tm2CxdTgKRT5cre5132JljBrca1tm1Cxd
• increased keratinocyte proliferation_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0009583I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0TgKRT5E2F12Dgj0TgKRT5cre5132JljBrca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased keratinocyte proliferation_Brca1<tm2Cxd>/Brca1<+>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0009583I129S6SvEvTacC57BL6SJLBrca1tm2CxdBrca1TgKRT5E2F12Dgj0Brca1tm2CxdBrca1TgKRT5E2F12Dgj
• abnormal epidermal layer morphology_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0001216I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5E2F12Dgj0Brca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• decreased tumor latency_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0010308I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0TgKRT5E2F12Dgj0TgKRT5cre5132JljBrca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• preweaning lethality, incomplete penetrance_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0011110I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0TgKRT5E2F12Dgj0TgKRT5cre5132JljBrca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased mouth tumor incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0003750I129S6SvEvTacC57BL6Brca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0Brca1tm2CxdTgKRT5cre5132JljBrca1tm1Cxd
• abnormal epidermal layer morphology_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0001216I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0TgKRT5E2F12Dgj0TgKRT5cre5132JljBrca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased reproductive system tumor incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0010287I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5E2F12Dgj0Brca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased mouth tumor incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0003750I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5E2F12Dgj0Brca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased skin tumor incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0010300I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5E2F12Dgj0Brca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased squamous cell carcinoma incidence_Brca1<tm2Cxd>/Brca1<+>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0004207I129S6SvEvTacC57BL6SJLBrca1tm2CxdBrca1TgKRT5E2F12Dgj0Brca1tm2CxdBrca1TgKRT5E2F12Dgj
• increased squamous cell carcinoma incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0004207I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5E2F12Dgj0Brca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased squamous cell carcinoma incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0004207I129S6SvEvTacC57BL6Brca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0Brca1tm2CxdTgKRT5cre5132JljBrca1tm1Cxd
• abnormal epidermal layer morphology_Brca1<tm2Cxd>/Brca1<+>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0001216I129S6SvEvTacC57BL6SJLBrca1tm2CxdBrca1TgKRT5E2F12Dgj0Brca1tm2CxdBrca1TgKRT5E2F12Dgj
• increased papilloma incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0002014I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5E2F12Dgj0Brca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased squamous cell carcinoma incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0004207I129S6SvEvTacC57BL6SJLBrca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0TgKRT5E2F12Dgj0TgKRT5cre5132JljBrca1tm2CxdTgKRT5E2F12DgjBrca1tm1Cxd
• increased tumor incidence_Brca1<tm2Cxd>/Brca1<+>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0002020I129S6SvEvTacC57BL6SJLBrca1tm2CxdBrca1TgKRT5E2F12Dgj0Brca1tm2CxdBrca1TgKRT5E2F12Dgj
• abnormal epidermal layer morphology_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001216I129S6SvEvTacC57BL6Brca1tm1CxdBrca1tm2CxdTgKRT5cre5132Jlj0Brca1tm2CxdTgKRT5cre5132JljBrca1tm1Cxd
• increased skin tumor incidence_Brca1<tm2Cxd>/Brca1<+>,Tg(KRT5-E2F1)2Dgj/0
  http://metadb.riken.jp/0010300I129S6SvEvTacC57BL6SJLBrca1tm2CxdBrca1TgKRT5E2F12Dgj0Brca1tm2CxdBrca1TgKRT5E2F12Dgj