increased basal cell carcinoma incidence_Dicer1<tm1Snj>/Dicer1<tm1Snj>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/0

http://metadb.riken.jp/0004208I129P2OlaHsd129S7SvEvBrdC57BL6NFVBNICRDicer1tm1SnjDicer1tm1SnjTrp53tm1BrnTrp53TgKRT5crePGR1Der0Trp53Dicer1tm1SnjTgKRT5crePGR1DerTrp53tm1Brn

increased basal cell carcinoma incidence_Dicer1<tm1Snj>/Dicer1<tm1Snj>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Dennis R Roop
  http://metadb.riken.jp/db/mgi_rdf/MGI:2651407
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• dicer 1, ribonuclease type III
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177178

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Dicer1<tm1Snj>/Dicer1<tm1Snj>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<+>|Dicer1<tm1Snj>|Tg(KRT5-cre/PGR)1Der|Trp53<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased basal cell carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0004208

文献

http://purl.org/net/cito/citesAsAuthority

• Stephen. Lyle, et.al., Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice., PloS one, 2014, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/24979267