decreased cellular sensitivity to ionizing radiation_Brca2<tm1Mak>/Brca2<tm2Mak>,Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(Lck-cre)548Jxm/0

http://metadb.riken.jp/0004228I129P2OlaHsd129S7SvEvBrdC57BL6CBABrca2tm1MakBrca2tm2MakTrp53tm1BrdTrp53tm1BrdTgLckcre548Jxm0Brca2tm2MakTrp53tm1BrdTgLckcre548JxmBrca2tm1Mak

decreased cellular sensitivity to ionizing radiation_Brca2<tm1Mak>/Brca2<tm2Mak>,Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(Lck-cre)548Jxm/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• breast cancer 2, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:109337
• transgene insertion 548, Jamey Marth
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176198

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca2<tm1Mak>/Brca2<tm2Mak>,Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(Lck-cre)548Jxm/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Brca2<tm2Mak>|Trp53<tm1Brd>|Tg(Lck-cre)548Jxm|Brca2<tm1Mak>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased cellular sensitivity to ionizing radiation
  http://purl.obolibrary.org/obo/MP_0004228

文献

http://purl.org/net/cito/citesAsAuthority

• Alison M Y. Cheung, et.al., Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis., Cancer research, 2002, 62
  http://rdf.ncbi.nlm.nih.gov/pubmed/12414647