Alison M Y. Cheung, et.al., Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis., Cancer research, 2002, 62

http://rdf.ncbi.nlm.nih.gov/pubmed/12414647

Alison M Y. Cheung, et.al., Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis., Cancer research, 2002, 62

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Brca2<tm2Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2429691

class

http://purl.org/net/cito/citesAsAuthority

• Brca2<tm2Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2429691

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased lymphoma incidence_Brca2<tm1Mak>/Brca2<tm2Mak>,Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0012431I129P2OlaHsd129S7SvEvBrdC57BL6CBABrca2tm1MakBrca2tm2MakTrp53tm1BrdTrp53tm1BrdTgLckcre548Jxm0Brca2tm2MakTrp53tm1BrdTgLckcre548JxmBrca2tm1Mak
• abnormal chromosome morphology_Brca2<tm1Mak>/Brca2<tm2Mak>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0003702I129P2OlaHsdC57BL6CBABrca2tm1MakBrca2tm2MakTgLckcre548Jxm0Brca2tm1MakTgLckcre548JxmBrca2tm2Mak
• increased osteosarcoma incidence_Brca2<tm1Mak>/Brca2<tm2Mak>,Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0003789I129P2OlaHsd129S7SvEvBrdC57BL6CBABrca2tm1MakBrca2tm2MakTrp53tm1BrdTrp53tm1BrdTgLckcre548Jxm0Brca2tm2MakTrp53tm1BrdTgLckcre548JxmBrca2tm1Mak
• no abnormal phenotype detected_Brca2<tm2Mak>/Brca2<tm2Mak>
  http://metadb.riken.jp/0002169I129P2OlaHsdC57BL6Brca2tm2MakBrca2tm2MakBrca2tm2Mak
• increased activated T cell number_Brca2<tm1Mak>/Brca2<tm2Mak>,Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0001829I129P2OlaHsd129S7SvEvBrdC57BL6CBABrca2tm1MakBrca2tm2MakTrp53tm1BrdTrp53tm1BrdTgLckcre548Jxm0Brca2tm2MakTrp53tm1BrdTgLckcre548JxmBrca2tm1Mak
• decreased cellular sensitivity to ionizing radiation_Brca2<tm1Mak>/Brca2<tm2Mak>,Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0004228I129P2OlaHsd129S7SvEvBrdC57BL6CBABrca2tm1MakBrca2tm2MakTrp53tm1BrdTrp53tm1BrdTgLckcre548Jxm0Brca2tm2MakTrp53tm1BrdTgLckcre548JxmBrca2tm1Mak
• abnormal chromosome morphology_Brca2<tm1Mak>/Brca2<tm2Mak>,Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0003702I129P2OlaHsd129S7SvEvBrdC57BL6CBABrca2tm1MakBrca2tm2MakTrp53tm1BrdTrp53tm1BrdTgLckcre548Jxm0Brca2tm2MakTrp53tm1BrdTgLckcre548JxmBrca2tm1Mak
• increased tumor incidence_Brca2<tm1Mak>/Brca2<tm2Mak>,Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0002020I129P2OlaHsd129S7SvEvBrdC57BL6CBABrca2tm1MakBrca2tm2MakTrp53tm1BrdTrp53tm1BrdTgLckcre548Jxm0Brca2tm2MakTrp53tm1BrdTgLckcre548JxmBrca2tm1Mak
• increased T cell apoptosis_Brca2<tm1Mak>/Brca2<tm2Mak>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0006413I129P2OlaHsdC57BL6CBABrca2tm1MakBrca2tm2MakTgLckcre548Jxm0Brca2tm1MakTgLckcre548JxmBrca2tm2Mak
• aneuploidy_Brca2<tm1Mak>/Brca2<tm2Mak>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0004024I129P2OlaHsdC57BL6CBABrca2tm1MakBrca2tm2MakTgLckcre548Jxm0Brca2tm1MakTgLckcre548JxmBrca2tm2Mak
• increased malignant tumor incidence_Brca2<tm1Mak>/Brca2<tm2Mak>,Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0002018I129P2OlaHsd129S7SvEvBrdC57BL6CBABrca2tm1MakBrca2tm2MakTrp53tm1BrdTrp53tm1BrdTgLckcre548Jxm0Brca2tm2MakTrp53tm1BrdTgLckcre548JxmBrca2tm1Mak