increased incidence of tumors by chemical induction_Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>,Cdkn2b<tm2Brn>/Cdkn2b<tm2Brn>

http://metadb.riken.jp/0004499I129P2OlaHsdFVBNCdkn2atm11BrnCdkn2atm11BrnCdkn2btm2BrnCdkn2btm2BrnCdkn2btm2BrnCdkn2atm11Brn

increased incidence of tumors by chemical induction_Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>,Cdkn2b<tm2Brn>/Cdkn2b<tm2Brn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  http://metadb.riken.jp/db/mgi_rdf/MGI:104737
• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>,Cdkn2b<tm2Brn>/Cdkn2b<tm2Brn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdkn2b<tm2Brn>|Cdkn2a<tm1.1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased incidence of tumors by chemical induction
  http://purl.obolibrary.org/obo/MP_0004499

文献

http://purl.org/net/cito/citesAsAuthority

• Paul. Krimpenfort, et.al., p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a., Nature, 2007, 448
  http://rdf.ncbi.nlm.nih.gov/pubmed/17713536