Paul. Krimpenfort, et.al., p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a., Nature, 2007, 448

http://rdf.ncbi.nlm.nih.gov/pubmed/17713536

Paul. Krimpenfort, et.al., p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a., Nature, 2007, 448

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Del(4Cdkn2a-Cdkn2b)2Brn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3767464
• Cdkn2b<tm2Brn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3767459
• Cdkn2b<tm1Brn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3766012
• Del(4Cdkn2a-Cdkn2b)1Brn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3790457

class

http://purl.org/net/cito/citesAsAuthority

• Del(4Cdkn2a-Cdkn2b)2Brn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3767464
• Cdkn2b<tm2Brn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3767459
• Cdkn2b<tm1Brn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3766012
• Del(4Cdkn2a-Cdkn2b)1Brn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3790457

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased tumor incidence_Del(4Cdkn2a-Cdkn2b)2Brn/+
  http://metadb.riken.jp/0002020I129P2OlaHsdFVBNDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2Brn
• increased melanoma incidence_Del(4Cdkn2a-Cdkn2b)2Brn/+
  http://metadb.riken.jp/0010275I129P2OlaHsdFVBNDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2Brn
• increased intestinal adenocarcinoma incidence_Del(4Cdkn2a-Cdkn2b)2Brn/+
  http://metadb.riken.jp/0002957I129P2OlaHsdFVBNDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2Brn
• increased tumor latency_Del(4Cdkn2a-Cdkn2b)2Brn/Del(4Cdkn2a-Cdkn2b)2Brn
  http://metadb.riken.jp/0009828I129P2OlaHsdFVBNDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2Brn
• increased skin tumor incidence_Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>,Cdkn2b<tm2Brn>/Cdkn2b<tm2Brn>
  http://metadb.riken.jp/0010300I129P2OlaHsdFVBNCdkn2atm11BrnCdkn2atm11BrnCdkn2btm2BrnCdkn2btm2BrnCdkn2btm2BrnCdkn2atm11Brn
• increased lymphoma incidence_Del(4Cdkn2a-Cdkn2b)1Brn/+
  http://metadb.riken.jp/0012431I129P2OlaHsdDel4Cdkn2aCdkn2b1BrnDel4Cdkn2aCdkn2b1Brn
• increased intestinal adenoma incidence_Del(4Cdkn2a-Cdkn2b)1Brn/+
  http://metadb.riken.jp/0002404I129P2OlaHsdDel4Cdkn2aCdkn2b1BrnDel4Cdkn2aCdkn2b1Brn
• increased tumor incidence_Del(4Cdkn2a-Cdkn2b)2Brn/Del(4Cdkn2a-Cdkn2b)2Brn
  http://metadb.riken.jp/0002020I129P2OlaHsdFVBNDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2Brn
• increased sarcoma incidence_Del(4Cdkn2a-Cdkn2b)1Brn/+
  http://metadb.riken.jp/0002032I129P2OlaHsdDel4Cdkn2aCdkn2b1BrnDel4Cdkn2aCdkn2b1Brn
• increased tumor incidence_Del(4Cdkn2a-Cdkn2b)1Brn/+
  http://metadb.riken.jp/0002020I129P2OlaHsdDel4Cdkn2aCdkn2b1BrnDel4Cdkn2aCdkn2b1Brn
• increased leukemia incidence_Del(4Cdkn2a-Cdkn2b)1Brn/+
  http://metadb.riken.jp/0002026I129P2OlaHsdDel4Cdkn2aCdkn2b1BrnDel4Cdkn2aCdkn2b1Brn
• increased incidence of tumors by chemical induction_Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>,Cdkn2b<tm2Brn>/Cdkn2b<tm2Brn>
  http://metadb.riken.jp/0004499I129P2OlaHsdFVBNCdkn2atm11BrnCdkn2atm11BrnCdkn2btm2BrnCdkn2btm2BrnCdkn2btm2BrnCdkn2atm11Brn
• increased sarcoma incidence_Del(4Cdkn2a-Cdkn2b)2Brn/+
  http://metadb.riken.jp/0002032I129P2OlaHsdFVBNDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2Brn
• increased tumor incidence_Del(4Cdkn2a-Cdkn2b)1Brn/Del(4Cdkn2a-Cdkn2b)1Brn
  http://metadb.riken.jp/0002020I129P2OlaHsdDel4Cdkn2aCdkn2b1BrnDel4Cdkn2aCdkn2b1BrnDel4Cdkn2aCdkn2b1Brn
• increased leukemia incidence_Del(4Cdkn2a-Cdkn2b)2Brn/+
  http://metadb.riken.jp/0002026I129P2OlaHsdFVBNDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2Brn
• increased lymphoma incidence_Del(4Cdkn2a-Cdkn2b)2Brn/+
  http://metadb.riken.jp/0012431I129P2OlaHsdFVBNDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2Brn
• increased skin tumor incidence_Del(4Cdkn2a-Cdkn2b)2Brn/+
  http://metadb.riken.jp/0010300I129P2OlaHsdFVBNDel4Cdkn2aCdkn2b2BrnDel4Cdkn2aCdkn2b2Brn
• increased skin tumor incidence_Del(4Cdkn2a-Cdkn2b)1Brn/+
  http://metadb.riken.jp/0010300I129P2OlaHsdDel4Cdkn2aCdkn2b1BrnDel4Cdkn2aCdkn2b1Brn
• decreased incidence of tumors by chemical induction_Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>
  http://metadb.riken.jp/0004502I129P2OlaHsdFVBNCdkn2atm11BrnCdkn2atm11BrnCdkn2atm11Brn