increased incidence of tumors by chemical induction_Kras<tm4Tyj>/Kras<+>,Trp53<tm3Glo>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?

http://metadb.riken.jp/0004499I129SvC57BL6FVBICRKrastm4TyjKrasTrp53tm3GloTrp53TgKRT5crePGR1DerTrp53Krastm4TyjTgKRT5crePGR1DerTrp53tm3GloKras

increased incidence of tumors by chemical induction_Kras<tm4Tyj>/Kras<+>,Trp53<tm3Glo>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transgene insertion 1, Dennis R Roop
  http://metadb.riken.jp/db/mgi_rdf/MGI:2651407
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Trp53<tm3Glo>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<+>|Kras<tm4Tyj>|Tg(KRT5-cre/PGR)1Der|Trp53<tm3Glo>|Kras<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * C57BL/6 * FVB * ICR

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased incidence of tumors by chemical induction
  http://purl.obolibrary.org/obo/MP_0004499

文献

http://purl.org/net/cito/citesAsAuthority

• Carlos. Caulin, et.al., An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations., The Journal of clinical investigation, 2007, 117
  http://rdf.ncbi.nlm.nih.gov/pubmed/17607363