increased susceptibility to autoimmune diabetes_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0

http://metadb.riken.jp/0004803I129C57BL6NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTnfrsf4tm2creNikTnfrsf4TgTcraBDC25TcrbBDC251Doi0Tgfbr2tm12HlmTgTcraBDC25TcrbBDC251DoiTnfrsf4tm2creNikTnfrsf4

increased susceptibility to autoimmune diabetes_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• tumor necrosis factor receptor superfamily, member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:104512
• transforming growth factor, beta receptor II
  http://metadb.riken.jp/db/mgi_rdf/MGI:98729
• transgene insertion 1, Christophe Benoist
  http://metadb.riken.jp/db/mgi_rdf/MGI:3612117

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tgfbr2<tm1.2Hlm>|Tg(TcraBDC2.5,TcrbBDC2.5)1Doi|Tnfrsf4<tm2(cre)Nik>|Tnfrsf4<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * NOD * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased susceptibility to autoimmune diabetes
  http://purl.obolibrary.org/obo/MP_0004803

文献

http://purl.org/net/cito/citesAsAuthority

• Harumichi. Ishigame, et.al., Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110
  http://rdf.ncbi.nlm.nih.gov/pubmed/23569233