increased hematopoietic stem cell number_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?

http://metadb.riken.jp/0004809I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf

increased hematopoietic stem cell number_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• tet methylcytosine dioxygenase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:2443298
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072
• splicing factor 3b, subunit 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1932339

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Mx1-cre)1Cgn|Sf3b1<+>|Tet2<tm1.1Iaai>|Sf3b1<tm1.1Mdf>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased hematopoietic stem cell number
  http://purl.obolibrary.org/obo/MP_0004809

文献

http://purl.org/net/cito/citesAsAuthority

• Esther A. Obeng, et.al., Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation., Cancer cell, 2016, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/27622333