Esther A. Obeng, et.al., Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation., Cancer cell, 2016, 30

http://rdf.ncbi.nlm.nih.gov/pubmed/27622333

Esther A. Obeng, et.al., Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation., Cancer cell, 2016, 30

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sf3b1<tm1.1Mdf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5818977

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal erythropoiesis_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000245I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• abnormal erythropoiesis_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000245I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
• abnormal erythropoiesis_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000245I129SSvEvC57BL6CBATet2tm11IaaiTet2tm11IaaiTgMx1cre1Cgn0TgMx1cre1CgnTet2tm11Iaai
• macrocytosis_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000248I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• macrocytosis_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000248I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
• increased granulocyte number_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000322I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
他23件を見る
• increased granulocyte number_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000322I129SSvEvC57BL6CBATet2tm11IaaiTet2tm11IaaiTgMx1cre1Cgn0TgMx1cre1CgnTet2tm11Iaai
• enlarged spleen_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000691I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
• enlarged spleen_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691I129SSvEvC57BL6CBATet2tm11IaaiTet2tm11IaaiTgMx1cre1Cgn0TgMx1cre1CgnTet2tm11Iaai
• abnormal myelopoiesis_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0001601I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• abnormal myelopoiesis_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0001601I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
• abnormal myelopoiesis_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001601I129SSvEvC57BL6CBATet2tm11IaaiTet2tm11IaaiTgMx1cre1Cgn0TgMx1cre1CgnTet2tm11Iaai
• impaired hematopoiesis_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0001606I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• premature death_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• abnormal megakaryocyte morphology_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0002417I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
• increased mean corpuscular volume_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0002590I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• increased mean corpuscular volume_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0002590I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
• decreased erythrocyte cell number_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0002875I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• increased hematopoietic stem cell number_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0004809I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• increased hematopoietic stem cell number_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0004809I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
• increased hematopoietic stem cell number_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004809I129SSvEvC57BL6CBATet2tm11IaaiTet2tm11IaaiTgMx1cre1Cgn0TgMx1cre1CgnTet2tm11Iaai
• decreased B cell number_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0005017I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
• decreased B cell number_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005017I129SSvEvC57BL6CBATet2tm11IaaiTet2tm11IaaiTgMx1cre1Cgn0TgMx1cre1CgnTet2tm11Iaai
• hypochromic macrocytic anemia_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008389I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• hypochromic macrocytic anemia_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008389I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
• abnormal erythroid progenitor cell morphology_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008801I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• abnormal erythroid progenitor cell morphology_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008801I129SSvEv129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1Tet2tm11IaaiTet2tm11IaaiTgMx1cre1CgnTgMx1cre1CgnSf3b1Tet2tm11IaaiSf3b1tm11Mdf
• increased circulating erythropoietin level_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0011285I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf
• decreased granulocyte monocyte progenitor cell number_Sf3b1<tm1.1Mdf>/Sf3b1<+>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0013697I129S4SvJaeC57BL6CBAJSf3b1tm11MdfSf3b1TgMx1cre1CgnSf3b1TgMx1cre1CgnSf3b1tm11Mdf

class

http://purl.org/net/cito/citesAsAuthority

• Sf3b1<tm1.1Mdf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5818977