decreased hematopoietic stem cell number_Fbxw7<tm1Iaai>/Fbxw7<tm1Iaai>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0004810I129C57BL6CBAFbxw7tm1IaaiFbxw7tm1IaaiTgMx1cre1Cgn0Fbxw7tm1IaaiTgMx1cre1Cgn

decreased hematopoietic stem cell number_Fbxw7<tm1Iaai>/Fbxw7<tm1Iaai>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072
• F-box and WD-40 domain protein 7
  http://metadb.riken.jp/db/mgi_rdf/MGI:1354695

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Fbxw7<tm1Iaai>/Fbxw7<tm1Iaai>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Fbxw7<tm1Iaai>|Tg(Mx1-cre)1Cgn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased hematopoietic stem cell number
  http://purl.obolibrary.org/obo/MP_0004810

文献

http://purl.org/net/cito/citesAsAuthority

• Bryan. King, et.al., The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability., Cell, 2013, 153
  http://rdf.ncbi.nlm.nih.gov/pubmed/23791182