Bryan. King, et.al., The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability., Cell, 2013, 153

http://rdf.ncbi.nlm.nih.gov/pubmed/23791182

Bryan. King, et.al., The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability., Cell, 2013, 153

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Eef1a1<tm1(FBXW7*)Iaai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5524154
• Fbxw7<tm2Iaai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5524152

class

http://purl.org/net/cito/citesAsAuthority

• Eef1a1<tm1(FBXW7*)Iaai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5524154
• Fbxw7<tm2Iaai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5524152

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal hematopoietic stem cell physiology_Fbxw7<tm1Iaai>/Fbxw7<tm1Iaai>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010763I129C57BL6CBAFbxw7tm1IaaiFbxw7tm1IaaiTgMx1cre1Cgn0Fbxw7tm1IaaiTgMx1cre1Cgn
• decreased tumor latency_Fbxw7<tm2Iaai>/Fbxw7<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010308IC57BL6CBAFbxw7tm2IaaiFbxw7TgMx1cre1Cgn0TgMx1cre1CgnFbxw7Fbxw7tm2Iaai
• decreased tumor latency_Eef1a1<tm1(FBXW7*)Iaai>/Eef1a1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010308IC57BL6CBAEef1a1tm1FBXW7IaaiEef1a1TgMx1cre1Cgn0Eef1a1tm1FBXW7IaaiTgMx1cre1CgnEef1a1
• decreased hematopoietic stem cell number_Fbxw7<tm1Iaai>/Fbxw7<tm1Iaai>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004810I129C57BL6CBAFbxw7tm1IaaiFbxw7tm1IaaiTgMx1cre1Cgn0Fbxw7tm1IaaiTgMx1cre1Cgn
• lethality, complete penetrance_Fbxw7<tm2Iaai>/Fbxw7<tm2Iaai>
  http://metadb.riken.jp/0011400IC57BL6Fbxw7tm2IaaiFbxw7tm2IaaiFbxw7tm2Iaai
• abnormal T cell differentiation_Fbxw7<tm1Iaai>/Fbxw7<tm1Iaai>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002145I129C57BL6CBAFbxw7tm1IaaiFbxw7tm1IaaiTgMx1cre1Cgn0Fbxw7tm1IaaiTgMx1cre1Cgn