abnormal class switch recombination_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>,Rev3l<tm1.1Diaz>/Rev3l<tm1.1Diaz>

http://metadb.riken.jp/0004816I129P2OlaHsd129X1SvJBALBcC57BL6C57BL6NTacGtROSA26Sortm1EYFPCosGtROSA26SorCd19tm1creCgnCd19Rev3ltm11DiazRev3ltm11DiazCd19GtROSA26SorRev3ltm11DiazCd19tm1creCgnGtROSA26Sortm1EYFPCos

abnormal class switch recombination_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>,Rev3l<tm1.1Diaz>/Rev3l<tm1.1Diaz>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• CD19 antigen
  http://metadb.riken.jp/db/mgi_rdf/MGI:88319
• REV3 like, DNA directed polymerase zeta catalytic subunit
  http://metadb.riken.jp/db/mgi_rdf/MGI:1337131
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>,Rev3l<tm1.1Diaz>/Rev3l<tm1.1Diaz>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cd19<+>|Gt(ROSA)26Sor<+>|Rev3l<tm1.1Diaz>|Cd19<tm1(cre)Cgn>|Gt(ROSA)26Sor<tm1(EYFP)Cos>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal class switch recombination
  http://purl.obolibrary.org/obo/MP_0004816

文献

http://purl.org/net/cito/citesAsAuthority

• Janssen. Daly, et.al., Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity., Journal of immunology (Baltimore, Md. : 1950), 2012, 188
  http://rdf.ncbi.nlm.nih.gov/pubmed/22547703