decreased mean systemic arterial blood pressure_Gna11<tm1Soff>/Gna11<tm1Soff>,Gnaq<tm2Soff>/Gnaq<tm2Soff>,X/Tg(Myh11-cre/ERT2)1Soff

http://metadb.riken.jp/0004876I129P2OlaHsd129S7SvEvBrdFVBNGna11tm1SoffGna11tm1SoffGnaqtm2SoffGnaqtm2SoffXTgMyh11creERT21SoffGnaqtm2SoffTgMyh11creERT21SoffGna11tm1Soff

decreased mean systemic arterial blood pressure_Gna11<tm1Soff>/Gna11<tm1Soff>,Gnaq<tm2Soff>/Gnaq<tm2Soff>,X/Tg(Myh11-cre/ERT2)1Soff

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• guanine nucleotide binding protein, alpha q polypeptide
  http://metadb.riken.jp/db/mgi_rdf/MGI:95776
• guanine nucleotide binding protein, alpha 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:95766
• transgene insertion 1, Stefan Offermanns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3819268

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gna11<tm1Soff>/Gna11<tm1Soff>,Gnaq<tm2Soff>/Gnaq<tm2Soff>,X/Tg(Myh11-cre/ERT2)1Soff

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gnaq<tm2Soff>|Tg(Myh11-cre/ERT2)1Soff|Gna11<tm1Soff>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased mean systemic arterial blood pressure
  http://purl.obolibrary.org/obo/MP_0004876

文献

http://purl.org/net/cito/citesAsAuthority

• Angela. Wirth, et.al., G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension., Nature medicine, 2008, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/18084302