abnormal positive T cell selection_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>,Tg(TcraH-Y,TcrbH-Y)71Vbo/?

http://metadb.riken.jp/0004919I129S4SvJaeC57BL6JDBA2JZap70tm21WeisZap70tm21WeisTgTcraHYTcrbHY71VboZap70tm21WeisTgTcraHYTcrbHY71Vbo

abnormal positive T cell selection_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>,Tg(TcraH-Y,TcrbH-Y)71Vbo/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• zeta-chain (TCR) associated protein kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:99613
• transgene insertion 71, Harald von Boehmer
  http://metadb.riken.jp/db/mgi_rdf/MGI:3044559

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Zap70<tm2.1Weis>/Zap70<tm2.1Weis>,Tg(TcraH-Y,TcrbH-Y)71Vbo/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Zap70<tm2.1Weis>|Tg(TcraH-Y,TcrbH-Y)71Vbo

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6J * DBA/2J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal positive T cell selection
  http://purl.obolibrary.org/obo/MP_0004919

文献

http://purl.org/net/cito/citesAsAuthority

• Lih-Yun. Hsu, et.al., A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity., The Journal of experimental medicine, 2009, 206
  http://rdf.ncbi.nlm.nih.gov/pubmed/19841086